Publications
2024
Ehrhardt M, Schreiber S, Duderstadt Y, Braun-Dullaeus R, Borucki K, Brigadski T, Müller NG, Leßmann V, Müller P.
Circadian rhythm of brain-derived neurotrophic factor in serum and plasma.
Exp Physiol. 2024 Aug 6. doi: 10.1113/EP091671. Epub ahead of print. PMID: 39105714.
Duderstadt Y, Schreiber S, Burtscher J, Schega L, Müller NG, Brigadski T, Braun-Dullaeus RC, Leßmann V, Müller P.
Controlled Hypoxia Acutely Prevents Physical Inactivity-Induced Peripheral BDNF Decline.
Int J Mol Sci. 2024 Jul 9;25(14):7536. doi: 10.3390/ijms25147536. PMID: 39062779; PMCID: PMC11276956.
Khodaie B, Edelmann E, Leßmann V.
Distinct GABAergic modulation of timing-dependent LTP in CA1 pyramidal neurons along the longitudinal axis of the mouse hippocampus.
iScience. 2024 Feb 22;27(3):109320. doi: 10.1016/j.isci.2024.109320. PMID: 38487018; PMCID: PMC10937841.
Behrendt T, Quisilima JI, Bielitzki R, Behrens M, Glazachev OS, Brigadski T, Leßmann V, Schega L.
Brain-Derived neurotrophic factor and inflammatory biomarkers are unaffected by acute and chronic intermittent hypoxic-hyperoxic exposure in geriatric patients: a randomized controlled trial.
Ann Med. 2024 Dec;56(1):2304650. doi: 10.1080/07853890.2024.2304650. Epub 2024 Jan 22. PMID: 38253008; PMCID: PMC10810628.
2023
Teng Z, Kartalou GI, Dagar S, Fraering PC, Lessmann V, Gottmann K.
A delay in vesicle endocytosis by a C-terminal fragment of N-cadherin enhances Aβ synaptotoxicity
Cell Death Discov. 2023 Dec 8;9(1):444. Doi: https://doi.org/10.1038/s41420-023-01739-w
Bramham CR, Lessmann V, Hannan AJ, Wang C, Catanese A, Boeckers TM, Zhang H.
Editorial: Synaptopathies: from bench to bedside.
Front Synaptic Neurosci. 2023 Sep 27;15:1291163. doi: 10.3389/fnsyn.2023.1291163. PMID: 37829658; PMCID: PMC10565501.
Nocke H, Meyer F, Lessmann V.
Flow down gradients: the problem of pressure in this physiology core concept
Adv Physiol Educ. 2023 Sep 1;47(3):461-475. doi: 10.1152/advan.00107.2022. Epub 2023 May 4. PMID: 37141431.
Leßmann V, Kartalou GI, Endres T, Pawlitzki M, Gottmann K.
Repurposing drugs against Alzheimer´s disease: can the anti-multiple sclerosis drug fingolimod (FTY720) effectively tackle inflammation processes in AD?
J Neural Transm (Vienna). 2023 Aug;130(8):1003-1012. Doi: https://doi.org/10.1007/s00702-023-02618-5 Epub 2023 Apr 4
2022
Bianchi D, Migliore R, Vitale P, Garad M, Pousinha PA, Marie H, Lessmann V, Migliore M.
Membrane electrical properties of mouse hippocampal CA1 pyramidal neurons during strong inputs
Biophys J. 2022 Feb 15;121(4):644-657. doi: 10.1016/j.bpj.2022.01.002. Epub 2022 Jan 6.
Cepeda-Prado EA*, Khodaie B*, Quiceno GD, Beythien S, Edelmann E and Leßmann V.
Calcium-Permeable AMPA Receptors Mediate Timing-Dependent LTP Elicited by Low Repeat Coincident Pre- and Postsynaptic Activity at Schaffer Collateral-CA1 Synapses.
Cerebal Cortex 32:1682-1703. *shared first authorship. doi.org/10.1093/cercor/bhab306
Structural and functional brain alterations in patients with myasthenia gravis
Brain-derived neurotrophic factor expression in serotonergic neurons improves stress resilience and promotes adult hippocampal neurogenesis
Prog Neurobiol. 2022 Oct;217:102333. doi: 10.1016/j.pneurobio.2022.102333. Epub 2022 Jul 22.
Ma X, Vuyyuru H, Munsch T, Endres T, Lessmann V, Meis S.
ProBDNF Dependence of LTD and Fear Extinction Learning in the Amygdala of Adult Mice
Cereb Cortex. 2022 Mar 30;32(7):1350-1364. doi: 10.1093/cercor/bhab265
2021
Behrendt T, Kirschnick F, Kröger L, Beileke P, Rezepin M, Brigadski T, Leßmann V, Schega L.
Comparison of the effects of open vs. closed skill exercise on the acute and chronic BDNF, IGF-1 and IL-6 response in older healthy adults
BMC Neurosci. 2021 Nov 25;22(1):71. doi: 10.1186/s12868-021-00675-8.
Impairment of Spike-Timing-Dependent Plasticity at Schaffer Collateral-CA1 Synapses in Adult APP/PS1 Mice Depends on Proximity of Aβ Plaques
Int J Mol Sci. Jan 30;22(3):1378. doi: 10.3390/ijms22031378.
Sci.Rep. Apr 20;11(1):8535. doi: 10.1038/s41598-021-87769-9
Harb M, Jagusch J, Durairaja A, Endres T, Leßmann V, Fendt M.
Transl Psychiatry. Apr 22;11(1):233.doi: 10.1038/s41398-021-01365-z
Wenxi Xing, Ana Dolabela de Lima, Thomas Voigt
The Structural E/I Balance Constrains the Early Development of Cortical Network Activity
Front. Cell. Neurosci., 19 July 2021 Volume 15 - 2021 | https://doi.org/10.3389/fncel.2021.687306
Harb A, Vogel N, Shaib A, Becherer U, Bruns D, Mohrmann R.
Auxiliary Subunits Regulate the Dendritic Turnover of AMPA Receptors in Mouse Hippocampal Neurons
Front Mol Neurosci. 2021 Aug 23;14:728498. doi: 10.3389/fnmol.2021.728498.
Houy S, Martins JS, Mohrmann R, Sørensen JB.
Methods Mol Biol;2233:233-251. doi: 10.1007/978-1-0716-1044-2_16.
2020
Editorial for the special issue neurotrophic factors
Cell Tissue Res.Oct;382(1):1-4. doi: 10.1007/s00441-020-03291-w.
The physiology of regulated BDNF release
Cell Tissue Res. Oct;382(1):15-45. doi: 10.1007/s00441-020-03253-2.
Golgi-Cox Impregnation Combined With Fluorescence Staining of Amyloid Plaques Reveals Local Spine Loss in an Alzheimer Mouse Model
J Neurosci Methods. Jul 15;341:108797. doi: 10.1016/j.jneumeth.2020.108797.
Müller P, Duderstadt Y, Lessmann V, Müller NG.
Lactate and BDNF: Key Mediators of Exercise Induced Neuroplasticity?
J Clin Med. Apr 15;9(4). pii: E1136. doi: 10.3390/jcm9041136.
Szibor M, Gizatullina Z, Gainutdinov T, Endres T, Debska-Vielhaber G, Kunz M, Karavasili N, Hallmann K, Schreiber F, Bamberger A, Schwarzer M, Doenst T, Heinze HJ, Leßmann V, Vielhaber S, Kunz WS, Gellerich FN
Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply
Biol Cem. Feb 24. pii: jbc.RA119.011902. doi: 10.1074/jbc.RA119.011902.
2019
L. Baldauf, T. Endres, J. Scholz, E. Kirches, D.M. Ward, V. Lessmann, K. Borucki, C. Mawrin
Mitoferrin-1 is required for brain energy metabolism and hippocampus-dependent memory
Neurosci Lett. Sep 26:134521. doi: 10.1016/j.neulet.2019.134521.
J. Leschik, R. Eckenstaler, T. Endres, T. Munsch, E. Edelmann, K. Richter, O. Kobler, K.D. Fischer, W. Zuschratter, T. Brigadski, B. Lutz, V. Lessmann
Prominent Postsynaptic and Dendritic Exocytosis of Endogenous BDNF Vesicles in BDNF-GFP Knock-in Mice
Mol. Neurobiol. Mar 30. doi: 10.1007/s12035-019-1551-0.
S. Meis, T. Endres, T. Munsch, V.Lessman
Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala.
Int J Mol Sci. Sep 3;20(17). pii: E4310. doi: 10.3390/ijms20174310.
S.M.G. Solinas, E. Edelmann, V. Leßmann, M. Migliore
A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP
PLoS Comput Biol. Apr 24;15(4):e1006975. doi: 10.1371/journal.pcbi.1006975.
M. Woelfer, M. Li, L. Colic, T. Liebe, X. Di, B. Biswal, J. Murrough, V. Lessmann, T. Brigadski, M. Walter
Ketamine-induced changes in plasma brain-derived neurotrophic factor (BDNF) levels are associated with the resting-state functional connectivity of the prefrontal cortex
World J Biol Psychiatry. Nov 4:1-15. doi: 10.1080/15622975.2019.1679391.
2018
A. Becke, P. Müller, M. Dordevic, V. Lessmann , T. Brigadski, N.G. Müller
Daily Intermittent Normobaric Hypoxia Over 2 Weeks Reduces BDNF Plasma Levels in Young Adults - A Randomized Controlled Feasibility Study
Front Physiol. Oct 1;9:1337. doi: 10.3389/fphys.2018.01337.
J. Dahlmann, G. Awad, C. Dolny, S. Weinert, K. Richter, K.D. Fischer, T. Munsch, V. Leßmann, M. Volleth, M. Zenker, Y. Chen, C. Merkl, A. Schnieke , H. Baraki, I. Kutschka, G. Kensah
Generation of functional cardiomyocytes from rat embryonic and induced pluripotent stem cells using feeder-free expansion and differentiation in suspension culture
PLoS One. Mar 7;13(3):e0192652. doi: 10.1371/journal.pone.0192652.
E. Edelmann, V. Lessmann
Dopaminergic innervation and modulation of hippocampal networks
Cell Tissue Res. Sep;373(3):711-727. doi: 10.1007/s00441-018-2800-7.
E. Edelmann, V. Lessmann
Analyzing synaptic plasticity at the single cell level with STDP.
Neuroforum 24(3): A1–A8. doi.org/10.1515/nf-2017-A064
F. Groessl, T. Munsch, S. Meis, J. Griessner, J. Kaczanowska, P. Pliota, D. Kargl, S. Badurek, K. Kraitsy, A. Rassoulpour, J. Zuber, V. Lessmann, W. Haubensak
Dorsal tegmental dopamine neurons gate associative learning of fear
Nat Neurosci. Jul;21(7):952-962. doi: 10.1038/s41593-018-0174-5.
S. Meis, T. Endres, T. Munsch, V. Lessmann
Presynaptic Regulation of Tonic Inhibition by Neuromodulatory Transmitters in the Basal Amygdala
Mol Neurobiol. Mar 20. doi: 10.1007/s12035-018-0984-1.
B. Michels, H. Zwaka, R. Bartels, O. Lushchak, K. Franke, T. Endres, M. Fendt, I. Song, M. Bakr, T. Budragchaa, B. Westermann, D. Mishra, C. Eschbach, S. Schreyer, A. Lingnau, C. Vahl, M. Hilker, R. Menzel, T. Kähne, V. Leßmann, A. Dityatev, L. Wessjohann, B. Gerber
Memory enhancement by ferulic acid ester across species
Sci Adv. Oct 24;4(10):eaat6994. doi: 10.1126/sciadv.aat6994.
K. Rehfeld, A. Lüders, A. Hökelmann, V. Lessmann, J. Kaufmann, T. Brigadski, P. Müller, N.G. Müller
Dance training is superior to repetitive physical exercise in inducing brain plasticity in the elderly
PLoS One. Jul 11;13(7):e0196636. doi: 10.1371/journal.pone.0196636.
C. Römmelt, T. Munsch, A. Drynda, V. Lessmann, C.H. Lohmann, J. Bertrand
Periprosthetic hypoxia as consequence of TRPM7 mediated cobalt influx in osteoblasts
J Biomed Mater Res B Appl Biomater. 2018 Dec 3. doi: 10.1002/jbm.b.34273.
2017
E. Edelmann, E. Cepeda-Prado, V. Lessmann
Coexistence of multiple types of synaptic plasticity in individual hippocampal CA1 pyramidal neurons
Front. Synaptic Neurosci. Mar 14;9:7. doi: 10.3389/fnsyn.2017.00007.
S. Meis, T. Endres, T. Munsch, V. Lessmann
The Relation Between Long-Term Synaptic Plasticity at Glutamatergic Synapses in the Amygdala and Fear Learning in Adult Heterozygous BDNF-Knockout Mice
Cereb Cortex. Feb 10:1-14. doi: 10.1093/cercor/bhx032.
P. Müller, K. Rehfeld, M. Schmicker, A. Hökelmann, M. Dordevic, V. Lessmann, T. Brigadski, J. Kaufmann, N.G. Müller
Evolution of Neuroplasticity in Response to Physical Activity in Old Age: The Case for Dancing
Front Aging Neurosci. Mar 14;9:56. doi: 10.3389/fnagi.2017.00056.
S.A. Raza, A. Albrecht, G. Çalışkan, B. Müller, Y.E. Demiray, S. Ludewig, S. Meis, N. Faber, R. Hartig, B. Schraven, V. Lessmann, H. Schwegler, O. Stork
HIPP neurons in the dentate gyrus mediate the cholinergic modulation of background context memory salience
Nat Commun. Aug 4;8(1):189. doi: 10.1038/s41467-017-00205-3.
2016
W. Jordan, H. Dobrowolny, S. Bahn, H.G. Bernstein, T. Brigadski, T. Frodl, B. Isermann, V. Lessmann, J. Pilz, A. Rodenbeck, K. Schiltz, E. Schwedhelm, H. Tumani, J. Wiltfang, P.C. Guest, J. Steiner
Oxidative stress in drug-naïve first episode patients with schizophrenia and major depression: effects of disease acuity and potential confounders
Eur Arch Psychiatry Clin Neurosci. Dec 2.(2016).
C. Bode, F. Richter, C. Spröte, T. Brigadski, A. Bauer, S. Fietz, J.M. Fritschy, A. Richter
Altered postnatal maturation of striatal GABAergic interneurons in a phenotypic animal model of dystonia
Exp Neurol. Oct 22. pii: S0014-4886(16)30344-2. doi: 10.1016/j.expneurol.2016.10.013.
L. Schega, B. Peter, T. Brigadski, V. Leßmann, B. Isermann, D. Hamacher, A. Törpel
Effect of intermittent normobaric hypoxia on aerobic capacity and cognitive function in older people
J Sci Med Sport. Apr 26. pii: S1440-2440(16)00063-3. doi: 10.1016/j.jsams.2016.02.012.
M. Fendt, Y. Kiyokawa, T. Endres
Editorial: Scents that Matter-from Olfactory Stimuli to Genes, Behaviors and Beyond
Front Neurosci. Feb 9;10:29. doi: 10.3389/fnins.2016.00029.
B. Seifert, R. Eckenstaler, R. Rönicke, J. Leschik, B. Lutz, K. Reymann, V. Lessmann, T. Brigadski
Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal Neurons
Neural Plast. 2016:4145708. doi: 10.1155/2016/4145708.
R. Eckenstaler, V. Lessmann, T. Brigadski
CAPS1 effects on intragranular pH and regulation of BDNF release from secretory granules in hippocampal neurons
J Cell Sci. Apr 1;129(7):1378-90. doi: 10.1242/jcs.178251.
2015
A. Maass, S. Düzel, T. Brigadski, M. Goerke, A. Becke, U. Sobieray, K. Neumann, M. Lövdén, U. Lindenberger, L. Bäckman, R. Braun-Dullaeus, D. Ahrens, H.J. Heinze, N.G. Müller, V. Lessmann, M. Sendtner, E. Düzel
Relationships of peripheral IGF-1, VEGF and BDNF levels to exercise-related changes in memory, hippocampal perfusion and volumes in older adults
Neuroimage., Nov 3. pii: S1053-8119(15)01015-0. doi: 10.1016/j.neuroimage.2015.10.084.
T. Baltz, T. Voigt
Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission
Front. Cell. Neurosci., 17 July;9:272.(2015).
E. Edelmann, E. Cepeda-Prado, M. Franck, P. Lichtenecker, T. Brigadski, V. Leßmann
Theta burst firing recruits BDNF release and signaling in postsynaptic CA1 neurons in spike timing-dependent LTP
Neuron, May 20;86(4):1041-54.(2015).
L. Psotta, C. Rockahr, M. Gruss, E. Kirches, K.A. Braun, V. Lessmann, J. Bock and T. Endres
Impact of an additional chronic BDNF reduction on learning performance in an Alzheimer mouse model
Front. Behav. Neurosci. Mar 20;9:58.(2015).
A. Petzold, L. Psotta, T. Brigadski, T. Endres, V. Lessmann
Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning
Neurobiology of Learning Memory, Apr;120:52-60.(2015).
Silva A, Naia L, Dominguez A, Ribeiro M, Rodrigues J, Vieira OV, Lessmann V, Rego AC
Overexpression of BDNF and FL-TrkB receptor ameliorate striatal neural survival in Huntington’s disease.
Neurodegenerative Disease 15(4):207-18.
S. Hessler, F. Zheng, S. Hartmann, A. Rittger, S. Lehnert, M. Völkel, M. Nissen, E. Edelmann, S. Saftig, M. Schwake, T. Huth and C. Alzheimer
β-secretase BACE1 regulates hippocampal and reconstituted M-currents in a β-subunit-like fashion
J Neurosci. Feb 25;35(8):3298-311.(2015).
2014
R. Kolarow, C.R. Kuhlmann, T. Munsch, C. Zehendner, T. Brigadski, HJ. Luhmann, V. Leßmann
BDNF-induced nitric oxide signals in cultured rat hippocampal neurons: time course, mechanism of generation, and effect on neurotrophin secretion
Front Cell Neurosci. Nov 7;8:323.(2014).
E. Edelmann, V. Leßmann, T. Brigadski
Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity
Neuropharmacology, Jan;76 Pt C:610-27.(2014).
T. Brigadski, V. Leßmann
BDNF: A regulator of learning and memory with clinical relevance.
e-Neuroforum. 03/2014; 5(1):1-11.
2013
B. Schulz-Klaus, V. Leßmann and T. Endres
BDNF-dependent consolidation of fear memories in the perirhinal cortex
Front. Behav. Neurosci. Dec 17;7:205.(2013).
J. Leschik, R. Eckenstaler, K. Nieweg, P. Lichtenecker, T. Brigadski, K. Gottmann, V. Leßmann and B. Lutz
Embryonic stem cells stably expressing BDNF-GFP exhibit a BDNF-release-dependent enhancement of neuronal differentiation
J Cell Sci. Nov 1;126(Pt 21):5062-73.(2013).
S. Westerholz, A.D. de Lima, T. Voigt
Thyroid hormone-dependent development of early cortical networks: temporal specificity and the contribution of trkB and mTOR pathways
Front. Cell. Neurosci. Aug 06. (2013).
J. Daniel, H.R. Polder, V. Leßmann, T. Brigadski
Single-cell juxtacellular transfection and recording technique
Pflugers Arch. Nov;465(11):1637-49.(2013).
E. Edelmann, V. Leßmann, T. Brigadski
Pre- and postsynaptic twists in BDNF secretion and action in synaptic plasticity
Neuropharmacology, Jan;76 Pt C:610-27.(2014).
S. Schildt, T. Endres, V. Leßmann, E. Edelmann
Acute and chronic interference with BDNF/TrkB-signaling impair LTP selectively at mossy fiber synapses in the CA3 region of mouse hippocampus
Neuropharmacology, Aug;71:247-54.(2013).
L. Psotta, V. Leßmann, T. Endres
Impaired fear extinction learning in adult heterozygous BDNF knock-out mice
Neurobiol Learn Mem. Apr 8;103C:34-38.(2013).
E. Edelmann, V. Leßmann
Dopamine regulates intrinsic excitability thereby gating successful induction of spike timing-dependent plasticity in CA1 of the hippocampus
Front. Neurosci. 7:25.(2013).
H. Nocke, F. Meyer, V. Leßmann
Aspects of Vascular Physiology in Clinical and Vascular Surgical Practice: Basic Principles of Vascular Mechanics
Zentralbl Chir. Jan 16.(2013).
2012
T. Endres, V. Leßmann
Age-dependent deficits in fear learning in heterozygous BDNF knock-out mice
Learn Mem. Nov 15;19(12):561-70.(2012).
T. Laudes, S. Meis, T. Munsch, V. Leßmann
Impaired transmission at corticothalamic excitatory inputs and intrathalamic GABAergic synapses in the ventrobasal thalamus of heterozygous BDNF knockout mice
Neuroscience, Oct 11;222:215-27.(2012).
S. Meis, T. Endres, V. Leßmann
Postsynaptic BDNF signaling regulates long-term potentiation at thalamo-amygdala afferents
J Physiol., Jan 1;590(Pt 1):193-208.(2012).
J. Klueva, A.D. de Lima, S. Meis, T. Voigt, T. Munsch
Hyperpolarization-Activated Cation Current Contributes to Spontaneous Network Activity in Developing Neocortical Cultures
Neurosignals, 20(1):35-47.(2012).
2011
V. Rankovic, P. Landgraf, T. Kanyshkova, P. Ehling, S.G. Meuth, M.R. Kreutz, T. Budde, T. Munsch
Modulation of Calcium-Dependent Inactivation of L-Type Ca Channels via β-Adrenergic Signaling in Thalamocortical Relay Neurons
PLoS One. 6(12).(2011).
E. Edelmann, V. Leßmann
Dopamine Modulates Spike Timing-Dependent Plasticity and Action Potential Properties in CA1 Pyramidal Neurons of Acute Rat Hippocampal Slices
Front Synaptic Neurosci. 3:6.(2011).
T. Baltz , A. Herzog, T. Voigt
Slow oscillating population activity in developing cortical networks: Models and experimental results
J Neurophys., Sep;106(3):1500-14.(2011).
H. Witte, C. Warnke, T. Voigt, A.D. de Lima, I. Ivanov, T. R. Vidakovic-Koch, K. Sundmacher and A. Krost
AlGaN/GaN-based HEMTs for electrical stimulation of neuronal cell cultures
J. Phys. D: Appl. Phys. 44 355501, Aug 16 (2011).
V. Leßmann, S. Stroh-Kaffei, V. Steinbrecher, E. Edelmann, T. Brigadski, W. Kilb, H.J. Luhmann
The expression mechanism of the residual LTP in the CA1 region of BDNF k.o. mice is insensitive to NO synthase inhibition
Brain Res., May 19;1391C:14-23.(2011).
S. Meis, O. Stork, T. Munsch
Neuropeptide S-Mediated Facilitation of Synaptic Transmission Enforces Subthreshold Theta Oscillations within the Lateral Amygdala
PLoS ONE, March 18;6(3): e18020.(2011).
2010
P. Coulon, T. Kanyshkova, T. Broicher, T. Munsch, N. Wettschureck, T. Seidenbecher, S.G. Meuth, S. Offermanns, H.-C. Pape, T. Budde
Activity modes in thalamocortical relay neurons are modulated by Gq /G11 family G-proteins - serotonergic and glutamatergic signaling
Front Cell Neurosci., Oct 4(132).(2010).
L. Yang, A. Seifert, D. Wu, X. Wang, V. Rankovic, H. Schröder, L.O. Brandenburg, V. Höllt, T. Koch
Role of phospholipase D2/phosphatidic acid signal transduction in micro- and delta-opioid receptor endocytosis
Mol Pharmacol., Jul 78(1):105-13.(2010).
T. Baltz, A.D. de Lima, T. Voigt
Contribution of GABAergic interneurons to the development of spontaneous activity patterns in cultured neocortical networks
Front Cell Neurosci., Jun 21(4):15.(2010).
A. Stan, K.N. Pielarski, T. Brigadski, N. Wittenmayer, O. Fedorchenko, A. Gohla, V. Leßmann, T. Dresbach, K. Gottmann
Essential cooperation of N-cadherin and neuroligin-1 in the transsynaptic control of vesicle accumulation
Proc Natl Acad Sci U S A., Jun 15;107(24):11116-21.(2010).
S. Westerholz, A.D. de Lima, T. Voigt
Regulation of early spontaneous network activity and GABAergic neurons development by thyroid hormone
Neuroscience., Jun 30;168(2):573-89.(2010).
V. Rankovic, P. Ehling, P. Coulon, P. Landgraf, M.R. Kreutz, T. Munsch, T. Budde
Intracellular Ca(2+) release-dependent inactivation of Ca(2+) currents in thalamocortical relay neurons
Eur J Neurosci., Feb 31(3):439-49.(2010).
2009
M. Rankovic, L. Jacob, V. Rankovic, L.O. Brandenburg, H. Schröder, V. Höllt, T. Koch
ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2
Cell Signal., Dec 21(12):1784-93.(2009).
T.E. Hartog, F. Dittrich, A.W. Pieneman, R.F. Jansen, C. Frankl-Vilches, V. Leßmann, C. Lilliehook, S.A. Goldman, M. Gahr
Brain-derived neurotrophic factor signaling in the HVC is required for testosterone-induced song of female canaries
J Neurosci., Dec 9;29(49):15511-9.(2009).
S.G. Meuth, A.M. Herrmann, O.J. Simon, V. Siffrin, N. Melzer, S. Bittner, P. Meuth, H.F. Langer, S. Hallermann, N. Boldakowa, J. Herz, T. Munsch, P. Landgraf, O. Aktas, M. Heckmann, V. Leßmann, T. Budde, B.C. Kieseier, F. Zipp, H. Wiendl
Cytotoxic CD8+ T cell-neuron interactions: perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death
J Neurosci., Dec 9;29(49):15397-409.(2009).
K. Gottmann, T. Mittmann, V. Leßmann
BDNF signaling in the formation, maturation and plasticity of glutamatergic and GABAergic synapses
Exp Brain Res., Dec 199(3-4):203-34.(2009).
X. Wang, B. Hu, A. Zieba, N.G. Neumann, M. Kasper-Sonnenberg, A. Honsbein, G. Hultqvist, T. Conze, W. Witt, C. Limbach, M. Geitmann, H. Danielson, R. Kolarow, G. Niemann, V. Leßmann, M.W. Kilimann
A protein interaction node at the neurotransmitter release site: domains of Aczonin/Piccolo, Bassoon, CAST, and rim converge on the N-terminal domain of Munc13-1
J Neurosci., Oct 7;29(40):12584-96.(2009).
T. Endres, M. Fendt
Aversion- vs fear-inducing properties of 2,4,5-trimethyl-3-thiazoline, a component of fox odor, in comparison with those of butyric acid
J Exp Biol., Aug 212(Pt 15):2324-7.(2009).
V. Leßmann, T. Brigadski
Mechanisms, locations, and kinetics of synaptic BDNF secretion: an update
Neurosci Res., Sep 65(1):11-22.(2009).
M. Mikhaylova, P.P. Reddy, T. Munsch, P. Landgraf, S.K. Suman, K.H. Smalla, E.D. Gundelfinger, Y. Sharma, M.R. Kreutz
Calneurons provide a calcium threshold for trans-Golgi network to plasma membrane trafficking
Proc Natl Acad Sci U S A, Jun 2;106(22):9093-8.(2009).
C.R. Kuhlmann,L. Librizzi, D. Closhen, T. Pflanzner, V. Leßmann, C.U. Pietrzik, M. de Curtis, H.J. Luhmann
Mechanisms of C-Reactive Protein-Induced Blood-Brain Barrier Disruption
Stroke, Apr 40(4):1458-66.(2009).
A.D. de Lima, A. Gieseler, T. Voigt
Relationship between GABAergic interneurons migration and early neocortical network activity
Dev Neurobiol., Feb 1-15;69(2-3):105-23.(2009).
N. Kuczewski, C. Porcher, V. Leßmann, I. MedinaI, J.L. Gaiarsa
Activity-Dependent Dendritic Release of BDNF and Biological Consequences
Mol Neurobiol., Feb 39(1):37-49.(2009).
X. Xia, V. Leßmann, T.F. Martin
Imaging of evoked dense-core-vesicle exocytosis in hippocampal neurons reveals long latencies and kiss-and-run fusion events
J Cell Sci., Jan 1;122(Pt 1):75-82.(2009).
I.L. Hanganu, A. Okabe, V. Leßmann, H.J. Luhmann
Cellular mechanisms of subplate-driven and cholinergic input-dependent network activity in the neonatal rat somatosensory cortex
Cereb Cortex, Jan 19(1):89-105.(2009).
S. Sauerzweig, T. Munsch, V. Leßmann, K.G. Reymann, H. Braun
A population of serumdeprivation-induced bone marrow stem cells (SD-BMSC) expresses marker typical for embryonic and neural stem cells
Exp Cell Res., Jan 1;315(1):50-66.(2009).
2008
M. Fendt, T. Endres
2,3,5-Trimethyl-3-thiazoline (TMT), a component of fox odor - just repugnant or really fear-inducing?
Neurosci Biobehav Rev., Sep 32(7):1259-66.(2008).
T. Endres, M. Fendt
Inactivation of the lateral septum blocks fox odor-induced fear behavior
Neuroreport., Apr 16;19(6):667-70.(2008).
N. Kuczewski, C. Porcher, V. Leßmann, I. Medina and J.-L. Gaiarsa
Back-propagating action potential: A key contributor in activity-dependent dendritic release of BDNF
Communicative & Integrative Biology, Oct/Nov/Dec vol.1, issue 2:153-155.(2008).
N. Kuczewski, C. Porcher, N. Ferrand, H. Fiorentino, C. Pellegrino, R. Kolarow, V. Leßmann, I. Medina, J.L. Gaiarsa
Backpropagating action potentials trigger dendritic release of BDNF during spontaneous network activity
J Neurosci., Jul 2;28(27):7013-23.(2008).
S. Meis, J.R. Bergado-Acosta, Y. Yanagawa, K. Obata, O. Stork, T. Munsch
Identification of a neuropeptide S responsive circuitry shaping amygdala activity via the endopiriform nucleus
PLoS ONE, Jul 16;3(7).(2008).
C.R.W. Kuhlmann, M. Gerigk, B. Bender, D. Closhen, V. Leßmann, H.J. Luhmann
Fluvastatin prevents glutamate-induced blood-brain-barrier disruption in vitro
Life Sci., Jun 18;82(25-26):1281-7.(2008).
N. Heck, A. Golbs, T. Riedemann, J.J. Jang Sun, V. Leßmann, H.J. Luhmann
Activity-dependent regulation of neuronal apoptosis in neonatal mouse cerebral cortex
Cereb Cortex, Jun 18(6):1335-49.(2008).
A.M. Martin, C. Kuhlmann, S. Trossbach, S. Jaeger, E. Waldron, A. Roebroek, H.J. Luhmann, A. Laatsch, S. Weggen, V. Leßmann, C.U. Pietrzik
The functional role of the second NPXY motif of the LRP1 beta -chain in tPA-mediated activation of NMDA receptors
J Biol Chem., May 2;283(18):12004-13.(2008).
I. Abidin, U.T. Eysel, V. Leßmann & T. Mittmann
Impaired GABAergic inhibition in the visual cortex of BDNF heterozygous knock out mice
Journal of Physiology, Apr 1;586(7):1885-901.(2008).
J. Klueva, S. Meis, A. D. de Lima, T. Voigt & T. Munsch
Developmental downregulation of GABAergic drive parallels formation of functional synapses in cultured mouse neocortical networks
Dev. Neurobiol., Jun 68(7):934-49.(2008).
T. Broicher, N. Wettschureck, T. Munsch, P. Coulon, S.G. Meuth, T. Seidenbecher, S. Offermanns, H.-C. Pape & T. Budde
Muscarinic Ach receptor-mediated control of thalamic activity via Gq/G11-family G-proteins
Pflügers Arch., Sep;456(6):1049-60.(2008).
2007
T. Endres, K. Widmann, M. Fendt
Are rats predisposed to learn 22 kHz calls as danger-predicting signals?
Behav Brain Res., Dec 28;185(2):69-75.(2007).
T. Endres, M. Fendt
Conditioned behavioral responses to a context paired with the predator odor trimethylthiazoline
Behav Neurosci., Jun;121(3):594-601.(2007).
R. Kolarow, T. Brigadski, V. Leßmann
Postsynaptic Secretion of BDNF and NT-3 from Hippocampal Neurons Depends on Calcium - Calmodulin Kinase II Signaling and Proceeds via Delayed Fusion Pore Opening
J Neurosci., Sep 26;27(39):10350-64.(2007).
C. R. Kuhlmann, R. Tamaki, M. Gamerdinger, V. Leßmann, C. Behl, O. S. Kempski, H. J. Luhmann
Inhibition of the myosin light chain kinase prevents hypoxia-induced blood-brain barrier disruption
J Neurochem., Jul 102(2):501-7.(2007).
A. D. de Lima, B. D. de Lima & T. Voigt
Earliest spontaneous activity differentially regulates neocortical GABAergic interneuron subpopulations
Eur.J.Neurosci., 25:1-16.(2007).
K. Kube, A. Herzog, B. Michaelis, A. D. de Lima & T. Voigt
Synchronization in complex dynamical networks
Computational Intelligence and Bioinformatics and Computational Biology, 2007. CIBCB apos, 07. IEEE Symposium on Volume , Issue, 1-5 April 2007 Page(s):426-431.(2007).
A. Herzog, K. Kube, B. Michaelis, AD. de Lima, and T. Voigt
Multi-population approach to approximate the development of neocortical networks
IEEE Congress on Evolutionary Computation - CEC 2007, Singapore, pages 628-633.(2007).
K. Kube, A. Herzog, B. Michaelis, AD. de Lima, and T. Voigt
Spike-timing-dependent plasticity in small world networks
Neurocomputing, accepted, 2007.
A. Herzog, K. Kube, B. Michaelis,A. D. de Lima & T. Voigt
Transition from initialization to working stage in biologically realistic networks
European Symposium on Artificial Neural Networks, pages 421-426.(2007).
A. Herzog, K. Kube, B. Michaelis, A. D. de Lima & T. Voigt
Displaced strategies optimize connectivity in neocortical networks
Neurocomputing, 70:1121-1129.(2007).
A. Herzog, K. Kube, B. Michaelis, A. D. de Lima & T. Voigt
Structural adaptation in young neocortical networks by spatially coupled oscillators
IEEE World Congress on Computational Intelligence - IJCNN ,Orlando,pages 3041-3044.(2007).
A. Herzog, K. Kube, B. Michaelis, A. D. de Lima & T. Voigt
Connection strategies in neocortical networks
ESANN Proc.,2006,215-220.(2007).
T. Broicher, T. Kanyshkova, P. Landgraf, V. Rankovic, P. Meuth, S.G. Meuth, H.-C. Pape & T. Budde
Specific expression of low-voltage-activated calcium channel isoforms and splice variants in thalamic local circuit interneurons
Mol. Cell. Neurosci., Oct 36(2):132-45.(2007).
T. Broicher, T. Seidenbecher, P. Meuth, T. Munsch, S.G. Meuth, T. Kanyshkova, H.-C. Pape & T. Budde
T-current related effects of antiepileptic drugs and a Ca2+ channel antagonist on thalamic relay and local circuit interneurons in a rat model of absence epilepsy
Neuropharmacol., Sep 53(3):431-46. (2007).
S. Meis, T. Munsch, L. Sosulina, H.-C. Pape
Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to cholecystokinin are mediated by a transient receptor potential-like current
Mol Cell Neurosci, Jun 35(2):356-67. (2007).
2006
I. Abidin, T. Köhler, E. Weiler, G. Zoidl, U. Eysel, V. Leßmann, T. Mittmann
Reduced presynaptic efficiency of excitatory synaptic transmission impairs LTP in the visual cortex of BDNF heterozygous mice
European Journal of Neuroscience, 24:3519-3531.(2006).
C. Walz, K. Jungling, V. Leßmann, K. Gottmann
Presynaptic plasticity in an immature neocortical network requires NMDA receptor activation and BDNF release
Journal of Neurophysiology, 96(6):3512-3516.(2006).
C. Kuhlmann, V. Leßmann, H. Luhmann
Fluvastatin stabilizes the blood-brain barrier in vitro by nitric oxide-dependent dephosphorylation of myosin light chains
Neuropharmacology 51(4):907-913.(2006).
K. Jungling, V. Eulenburg, R. Moore, R. Kemler, V. Leßmann, K. Gottmann
N-cadherin transsynaptically regulates short-term plasticity at glutamatergic synapses in embryonic stem cell-derived neurons
Journal of Neuroscience, 26(26):6968-6978.(2006).
A. Herzog, K. Kube, B. Michaelis, A. D. de Lima & T. Voigt
Liquid state machine by spatially coupled oscillators
ICNC 2006 Part I,LNCS,4221,980-983.(2006).
S. G. Meuth, I. M. Aller, T. Munsch, T. Schuhmacher, T. Seidenbecher, P. Meuth, C. Kleinschnitz, H.-C. Pape, H. Wiendl, W. Wisden, T. Budde
The contribution of TASK-1-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons
Mol Pharmacol., 69(4):1468-1476.(2006).
S. G. Meuth, T. Kanyshkova, P. Meuth, P. Landgraf, T. Munsch, A. Ludwig, F. Hofmann, H.-C. Pape & T. Budde
The membrane resting potential of thalamocortical relay neurons is shaped by the interaction among TASK3 and HCN2 channels
J Neurophysiol., 96:1517-1529.(2006).
L. Sosulina, S. Meis, G. Seifert, C. Steinhäuser, H.-C. Pape
Classification of projection neurons and interneurons in the rat lateral amygdala based upon cluster analysis
Mol Cell Neurosci., 33:57-67.(2006).