(Chronologically descending)

2023

Teng Z, Kartalou GI, Dagar S, Fraering PC, Lessmann V, Gottmann K. A delay in vesicle endocytosis by a C-terminal fragment of N-cadherin enhances Aβ synaptotoxicity. Cell Death Discov. 2023 Dec 8;9(1):444. Doi: https://doi.org/10.1038/s41420-023-01739-w

Leßmann V, Kartalou GI, Endres T, Pawlitzki M, Gottmann K. Repurposing drugs against Alzheimer´s disease: can the anti-multiple sclerosis drug fingolimod (FTY720) effectively tackle inflammation processes in AD? J Neural Transm (Vienna). 2023 Aug;130(8):1003-1012. Doi: https://doi.org/10.1007/s00702-023-02618-5 Epub 2023 Apr 4

Patil S, Chalkiadaki K, Mergiya TF, Krimbacher K, Amorim IS, Akerkar S, Gkogkas CG, Bramham CR. eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance. iScience. 2023 Apr 15;26(5):106649. Doi: https://doi.org/10.1016/j.isci.2023.106649

2022

Bianchi D, Migliore R, Vitale P, Garad M, Pousinha PA, Marie H, Lessmann V, Migliore M. Membrane electrical properties of mouse hippocampal CA1 pyramidal neurons during strong inputs. Biophys J. 2022 Feb 15;121(4):644-657. Doi: https://doi.org/10.1016/j.bpj.2022.01.002  Epub 2022 Jan 6

2021

Dagar S, Teng Z, Gottmann K. Transsynaptic N-Cadherin Adhesion Complexes Control Presynaptic Vesicle and Bulk Endocytosis at Physiological Temperature. Front Cell Neurosci. 2021 Oct 7;15:713693. Doi: https://doi.org/10.3389/fncel.2021.713693

Patil S, Endres T, Lessmann V, Bramham CR. Selective defect in LTP consolidation in vivo and impaired translation initiation in the dentate gyrus of amyloidgenic APP/PS1 transgenic mice. Science Matters. 2021 Apr 22. ISSN: 2297-8240

Winkel F, Ryazantseva M, Voigt MB, Didio G, Lilja A, Llach Pou M, Steinzeig A, Harkki J, Englund J, Khirug S, Rivera C, Palva S, Taira T, Lauri SE, Umemori J, Castrén E. Pharmacological and optical activation of TrkB in Parvalbumin interneurons regulate intrinsic states to orchestrate cortical plasticity. Mol Psychiatry. 2021 Dec;26(12):7247-7256. Doi: https://doi.org/10.1038/s41380-021-01211-0 Epub 2021 Jul 28.

Vitale P, Salgueiro-Pereira AR, Lupascu CA, Willem M, Migliore R, Migliore M, Marie H. Analysis of Age-Dependent Alterations in Excitability Properties of CA1 Pyramidal Neurons in an APPPS1 Model of Alzheimer´s Disease. Front Aging Neurosci. 2021 Jun 11;13:668948. Doi: https://doi.org/10.3389/fnagi.2021.668948

Casarotto P.C., Girych M., Fred S.M., Kovaleva, V., Moliner R., Enkavi G., Biojone C., Cannarozzo C., Sahu, M.P., Kaurinkoski, K., Brunello C.A., Steinzeig A., Winkel F., Patil S., Vestring S., Serchov T., Diniz C.R.A.F., Laukkanen L., Cardon I., Antila H., Rog T., Piepponen, T.P., Bramham C.R., Normann C., Lauri S.E., Saarma M., Vattulainen I., Castrén E. (2021) Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell 184, 1299-1313, https://doi.org/10.1016/j.cell.2021.01.034

Garad M, Edelmann E, Leßmann V. (2021) Impairment of Spike-Timing-Dependent Plasticity at Schaffer Collateral-CA1 Synapses in Adult APP/PS1 Mice Depends on Proximity of Aβ Plaques. Int J Mol Sci. 22(3):1378. https://doi.org/10.3390/ijms22031378

Harb M, Jagusch J, Durairaja A, Endres T, Leßmann V, Fendt M (2021) BDNFhaploinsufficiency induces behavioral endopheno-types of schizophrenia in male mice that arerescued by enriched environment. Transl Psychiatry. 2021 Apr 22;11(1):233. doi: https://doi.org/10.1038/s41398-021-01365-z

Lesnikova A., Casarotto P.C., Fred S.M., Voipio M, Winkel F., Steinzeig A., Antila H., Umemori J., Biojone C., and Castrén E. Chondroitinase and antidepressants promote plasticity by releasing TRKB
from dephosphorylating control of PTPσ in parvalbumin neurons. (2021) J. Neurosci. 41(5):972-980. https://doi.org/10.1523/jneurosci.2228-20.2020

Garad M, Edelmann E, Leßmann V (2021) Long-term depression at hippocampal mossy fiber-CA3 synapses involves BDNF but is not mediated by p75NTR signaling. Sci Rep. 2021 Apr20;11(1):8535. doi: https://doi.org/10.1038/s41598-021-87769-9

2020

De Sousa Maciel I., Sales A.J., Casarotto P.C., Castrén E., Biojone C., Samia R. L. Joca S.R.L. Nitric Oxide Synthase inhibition counteracts the stress-induced DNA methyltransferase 3b expression in the hippocampus of rats. (2020) Eur. J. Neurosci. Nov 10. Doi: https://doi.org/10.1111/ejn.15042

Kartalou GI, Salgueiro-Pereira AR, Endres T, Lesnikova A, Casarotto P, Pousinha P, Delanoe K, Edelmann E, Castrén E, Gottmann K, Marie H, Lessmann V (2020) Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model. Int J Mol Sci, 21, 8957. Doi: https://doi.org/10.3390/ijms21238957

Brigadski T, Lessmann V (2020) The physiology of regulated BDNF release. Cell Tissue Res. 382(1):15-45. Doi: https://doi.org/10.1007/s00441-020-03253-2

Meis S, Endres T, Lessmann V (2020) Neurotrophin signalling in amygdala-dependent cued fear learning. Cell Tissue Res. 382(1):161-172. Doi: https://doi.org/10.1007/s00441-020-03260-3

Muller P, Duderstadt Y, Lessmann V, Muller NG (2020) Lactate and BDNF: Key Mediators ofExercise Induced Neuroplasticity? J Clin Med. 2020 Apr 15;9(4):1136. doi: https://doi.org/10.3390/jcm9041136

Kartalou GI, Endres T, Lessmann V*, Gottmann K* (2020) Golgi-Cox impregnation combined with fluorescence staining of amyloid plaques reveals local spine loss in an Alzheimer mouse model. J Neurosci Methods 341:108797. Doi: https://doi.org/10.1016/j.jneumeth.2020.108797

Ehinger Y, Bruyère J, Panayotis N, Abada Y-S, Saidi L, Matagne V, Scaramuzzino C, Vitet H, Delatour B, Villard L, Saudou F, Roux J-C. (2020) Huntington phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 ko mice. EMBO Mol Med 12(2):e10889. Doi: https://doi.org/10.15252/emmm.201910889

2019

Fred S.M., Laukkanen L., Vesa L., Goos H., Cardon I., Moliner R., Maritzen T., Varjosalo M., Casarotto P.C., Castrén E. (2019) Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2. J Biol Chem 294(48):18150-18161. Doi: https://doi.org/10.1074/jbc.ra119.008837

Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo E, Zuccato C. (2019) Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington´s disease. J Clin Invest. 130:2390-2403. Doi: https://doi.org/10.1172/jci120616

Pousinha PA, Mouska X, Bianchi D, Temido-Ferreira M, Rajão-Saraiva J, Gomes R, Fernandez SP, Salgueiro-Pereira AR, Gandin C, Raymond EF, Barik J, Goutagny R, Bethus I, Lopes LV, Migliore M, Marie H. (2019) The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding. Cell Reports 29(2):317-331.e5. Doi: https://doi.org/10.1016/j.celrep.2019.08.103

Meis S, Endres T, Munsch T, Lessmann V. (2019) Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala. Int J Mol Sci. 20(17). Doi: https://doi.org/10.3390/ijms20174310

Solinas S, Edelmann E, Lessmann V, Migliore M. (2019) A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP. PLoS Computational Biology 15(4):e1006975. Doi: https://doi.org/10.1371/journal.pcbi.1006975

Lima-Ojeda J.M., Castrén E. (2019) BDNF and VEGF: Siamese twins in the antidepressant action. Biol. Psychiatry 86: 81-83. Doi: https://doi.org/10.1016/j.biopsych.2019.05.003

Steinzeig A., Cannarozzo C., Castrén E. Fluoxetine-induced plasticity in the visual cortex outlasts the duration of the naturally occurring critical period. (2019) Eur J. Neurosci. 50: 3663-3673, doi: 10.1111/ejn.14512. Doi: https://doi.org/10.1111/ejn.14512

Fonseca-Gomes, J., Jerónimo-Santos, A., Lesnikova, A., Casarotto, P., Castrén, E., Sebastião, A. M., and Diógenes, M. J. (2019). Trkb-icd fragment, originating from bdnf receptor cleavage, is translocated to cell nucleus and phosphorylates nuclear and axonal proteins. Frontiers in Mol Neurosci 12:4. Doi: https://doi.org/10.3389/fnmol.2019.00004

2018

Moutaux E, Christaller W, Scaramuzzino C, Genoux A, Charlot B, Cazorla M, Saudou F. (2018). Neuronal network matu¬ra¬tion differently affects secretory vesicles and mitochondria transport in axons. Scientific Reports. Sep 7;8(1):13429. Doi: https://doi.org/10.1038/s41598-018-31759-x

Michels B, Zwaka H, Bartels R, Lushchak O, Franke K, Endres T, Fendt M, Song I, Bakr M, Budragchaa T, Westermann B, Mishra D, Eschbach C, Schreyer S, Lingnau A, Vahl C, Hilker M, Menzel R, Kahne T, Lessmann V, Dityatev A, Wessjohann L, Gerber B. (2018) Memory enhancement by ferulic acid ester across species. Science Advances 4: eaat6994. Doi: https://doi.org/10.1126/sciadv.aat6994

Virlogeux A, Moutaux E, Christaller W, Genoux A, Bruyère J, Fino E, Charlot B, Cazorla M, Saudou F. (2018): Reconstituting Corticostriatal Network On-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington´s Disease. Cell Reports, Jan 2;22(1):110-122. Doi: https://doi.org/10.1016/j.celrep.2017.12.013

Umemori, J., Winkel, F., Didio, G., Llach Pou, M., Castren, E. (2018). Iplasticity: Induced juvenile-like plasticity in the adult brain as a mechanism of antidepressants. Psychiatry Clin Neurosci 72, 633-653. Doi: https://doi.org/10.1111/pcn.12683

Meis S, Endres T, Munsch T, Lessmann V. (2018) Presynaptic regulation of tonic inhibition byneuromodulatory transmitters in the basal amygdala Mol. Neurobiol. 55(11):8509-8521. doi: https://doi.org/10.1007/s12035-018-0984-1

2017

Nair RR, Patil S, Tiron A, Kanhema T, Panja D, Schiro L, Parobzak K, Wilczynski G, Bramham CR. (2017) Dynamic Arc SUMOylation and selective interaction with F-actin binding protein drebrin A in LTP consolidation in vivo. Front Synaptic Neurosci. Doi: https://doi.org/10.3389/fnsyn.2017.00008